Lm-33 Excersize Mimic Slu-pp-332

SLU-PP-332 is a synthetic small molecule recognized as a potent pan-agonist of estrogen-related receptors (ERRs), exhibiting the highest affinity for ERRα (EC₅₀ = 98 nM), followed by ERRβ (EC₅₀ = 230 nM) and ERRγ (EC₅₀ = 430 nM). This compound has garnered interest in metabolic research due to its role in enhancing mitochondrial function and cellular respiration in skeletal muscle cell lines. 

In preclinical studies, SLU-PP-332 has been observed to increase energy expenditure, promote fatty acid oxidation, reduce fat mass accumulation, and improve insulin sensitivity in mouse models of metabolic syndrome. Additionally, it has been shown to augment the proportion of fast oxidative skeletal muscle fibers (Type IIa) and enhance exercise endurance in mice in an ERRα-specific manner. ​

SLU-PP-332 functions by activating ERRs, which are pivotal in regulating energy metabolism, particularly in tissues with high energy demands such as muscles, the heart, and the brain. By binding to the ligand-binding domain of ERRα, SLU-PP-332 stabilizes its active conformation, facilitating interactions with coactivator proteins like PGC-1α, thereby promoting metabolic adaptations akin to those observed during endurance training. ​University of Florida News+1Wikipedia+1Wikipedia

This compound is intended strictly for research purposes and is not approved for human consumption. Researchers should handle SLU-PP-332 with appropriate safety protocols and adhere to all regulatory guidelines.